Archives for posts with tag: EPA

Statistics don’t care to be saved.

“As a physician, I am intrigued, if not put off, by the EPA concept of “premature deaths.” How am I to know that that unfortunate patient, who has just died, died prematurely? If asked, he would undoubtedly claim that he had died before his time, no matter the actual cause. All deaths are “premature” when viewed subjectively.” Dr. Charles Battig

Dr. Batting uses examples to explain why EPA rules will help no one. While reading Dr. Battig’s keep in mind that our air and water in the USA have gotten significantly cleaner every year since 1970 when we first started keeping track. Every year cleaner for 45 years. Our air and water are cleaner than they were 100 years ago? How clean do we need to be?

Cleaner than clean hurts.

The bottom line is the EPA rules will hurt the bottom line, especially for those with the lowest bottom line. EPA rules passed the point of diminishing returns long ago. The EPA causes far more harm than it mitigates. The EPA is the most dangerous thing known to mankind.

End the EPA.

The practical way to end the EPA is to repeal the Clean Air Act. I hope that is possible.

Political will will have to be high. Those voting to repeal the laws that empower the EPA must have sufficient backbone to take the name calling and threats.

The politicians will have to replace the laws, because we do actually need to protect our air and water, but the laws must be targeted and specifically limited in scope and control. Very specific. I expect that will cause some problems and confusion for a while as lawyers fight each other and politicians to iron out the details. Still, it has to be better than what we have.

EPA is killing us.

EPA is the most dangerous thing on earth.

The word is getting out. EPA is the most dangerous thing on earth. EPA does more harm to humanity than anything else, at least in the United States. Sure, there are more horrific terrors to combat. There are more noble causes to champion, but in order to fix the world our children are inheriting, we must reduce and remove regulation in our governments.

First, phase out and replace the EPA. Congress has the responsibility to repeal the outdated laws associated with our environmental regulations and replace them. The focus must be to eliminate bureaucracy.

Heartland has a plan:

They have a PDF here:


Gina McCarthy said. “And the great thing about this proposal is it really is an investment opportunity. This is not about pollution control.”

Ms. Jo pointed this out,

Dr. Roy Spencer, likewise,

With governmental regulation agencies, it’s always about the money; more money for their budget and more power and control for them.

Regulation is what will destroy this county, not taxes or deficits.


I’m watching the debate on News9 between James Lankford and TW Shannon.

The question asked was what each considered the greatest threat to the USA.

Both said the US debt. Shannon qualified that slightly.

I disagree. The greatest threat to the USA as we know it today is federal regulation. Specifically, the EPA is the greatest threat to the United States of America and what we are.

I applaud TW Shannon for actually stating (later) that we need to abolish the EPA. Yes. We must.

The EPA has become a monster that will destroy its creator, us. The EPA is the Frankenstein monster. It must be eliminated. We must repeal and replace the Clean Air Act with sensible, restricted, targeted legislation that makes sense for keeping our environment protected, but this replacement legislation must ensure citizens are not harassed and criminalized for building ponds on their own property. The new agencies to replace the EPA must be small, chartered, and limited, both in scope and in longevity. Such agencies should be chartered with Congressional oversight and not be put under full authority of the executive. Regulator agencies are law-givers, and thus must be under Congress, not the executive branch.

End the EPA. It is causing far more harm than good.

This is an important article:

Mr. Dennis T. Avery authored it, and it has been published in several publications.

We humans have been testing the theory that dose makes the poison for thousands of years. One can trust that hundreds of generations of people checking, and people trying to prove otherwise, would have succeeded. Accordingly, look for the data. Look for the results that show that there is more to harmful chemicals than just the dose.

You will find that it is not there.

Accordingly, one must conclude that either dose does make the poison, and at some level toxins become innocuous, or there is a huge conspiracy that hides all the information so that everyone will die.

Seeing that we ain’t dead yet, I’ll accept as fact that there is a safe level of lead in my diet.

I’m all for making easy choices in favor of eliminating possible problems. The easiest one is turning the power off of unused devices, like the lights.

That is, if I conserve the power, rather than leaving the light on for the convenience of not having to flip the switch nine hours later when I get home from work, then I will reduce an inefficiency, and I will be doing a small part in reserving the future resources needed to generate that power to provide the much-needed convenience of having light in my house to see by.

The fact is, it is much too easy to turn the light off, save the cost of the power, and turn the light on to justify leaving it on in the interim.

Bisphenol-A is a very useful and efficient plasticizer. While it may seem safe to avoid its use, one must think of the alternatives. Avoiding plasticizers, particularly BPA, has costs. Not using BPA will make plastics more expensive, and it will make the production processes more inefficient, and possibly more unhealthy in some other way. All in all, the costs and harm to society comes out high for banning of BPA, and such a decision is bad compared to the relatively proven case that BPA is not dangerous in any way at the levels encountered in our daily lives, even including our infants and their plastic baby bottles.

Unfortunately, Mr. Avery provided no references. I’m not finding anything recent.

I found this:

Quantitative Assessments of Genotoxicity Data

NCTR scientists are members of the Quantitative Analysis Workgroup of the HESI/ILSI Genetic Toxicology Technical Committee. The committee has developed best practices to analyze genetic toxicology data in a quantitative manner. Several dose-response modeling approaches using genotoxicity databases compiled by the workgroup were the basis for analysis. The workgroup found that a Benchmark Dose (BMD), which produces a 10% increase over the background response (BMD10), has the greatest utility as a Point of Departure (PoD) for establishing risk calculations. These recommendations were published in Environmental and Molecular Mutagenesis.

For additional information, please contact Robert H. Heflich, Ph.D., Division of Genetic and Molecular Toxicology, FDA/NCTR.

I assume that is not what he was referring to. It doesn’t seem to fit, but perhaps he meant this:

February 21
Toxicity Evaluation of Orally Administered BPA

NCTR scientists have published companion papers in Toxicological Sciences presenting data from:

The 90-day, Churchwell et al study provides new data for use to further refine physiologically based pharmacokinetic models used to extrapolate exposures in rodent tests to real world human exposures. The study is a component of the concurrently published subchronic range-finding study Delclos et al.

The second, Delclos et al study was used to determine doses and toxicological direction of the ongoing long-term (two-year) toxicological study currently under way at the FDA. The Delclos et al study results have been publicly available for some time. The results from the FDA’s long-term (two-year) study, which will include data generated by NIEHS-funded academic investigators, are expected to be release in early 2016.

For additional information, please contact Barry Delclos, Ph.D., or Daniel Doerge, Ph.D., Division of Biochemical Toxicology, FDA/NCTR.

Perhaps one of the references here:

March 28
Society for Toxicology Annual Meeting

On March 23-27, 2014, NCTR scientists gave platform presentations in continuing education courses and workshops, as well as poster presentations at the 53rd Annual Meeting and ToxExpo™ of the Society for Toxicology (SOT) in Phoenix, AZ. The presentations covered a wide range of topics including:

  • miRNA biomarkers of toxicity
  • imaging biomarkers
  • pediatric anesthetics
  • drug-induced liver injury
  • nanomaterials
  • results of studies with compounds of high FDA interest such as BPA, triclosan, furan, and melamine/cyanuric acid

Additionally, Dr. Annie Lumen received the “Best Postdoctoral Publication Award” for her paper on modeling effects of iodide and perchlorate exposure during human pregnancy (Toxicological Sciencesdisclaimer icon, 2013, 133: 320-341). The SOT is the premier professional society for toxicologists from academia, industry, and government.

Society for Toxicology Awards

An NCTR research article titled “Ketamine-Induced Neuronal Damage and Altered N-Methyl-D-Aspartate Receptor Function in Rat Primary Forebrain Culture” was one of 2013’s top ten most cited articles inToxicological Sciences. The in vitro study showed that ketamine, a common pediatric anesthetic, induces neuronal cell death through upregulation of the NMDA receptor; and L-carnitine is neuroprotective against ketamine’s adverse effects (Toxicological Sciencesdisclaimer icon, 2013, 131: 548-557). 

For additional information, contact Merle Paule, Ph.D., Director, Division of Neurotoxicology, FDA/NCTR.

Another NCTR research paper titled “Prediction and Ealuation of Route Dependent Dosimetry of BPA in Rats at Different Life Stages Using a Physiologically Based Pharmacokinetic Model” (Toxicol Appl Pharmacol, 270:45) was selected by a committee of the Risk Assessment Specialty Section as one of the Best Papers Published in 2013 Demonstrating Application of Risk Assessment.

A Postdoctoral Fellow in the Division of Biochemical Toxicology, received the SOT Carcinogenesis Specialty Section Postdoctoral Fellowship Award for the abstract entitled “Epigenetic alterations in the livers of Fisher 344 rats exposed to furan. The main focus of this study was to investigate the role of epigenetic alterations in the mechanisms of furan hepatotoxicity and carcinogenicity. The results of the study showed that exposure to furan causes dose-and time-dependent epigenetic aberrations that include alterations of DNA methylation status (global and gene-specific methylation), changes in the expression of chromatin modifying genes, and alterations in histone lysine methylation and acetylation patterns in the livers of male Fisher 344 rats. These findings significantly contribute to our understanding of the mechanisms of furan carcinogenesis and could be helpful for the future development of prevention strategies for early hepatic adverse effects associated with the furan exposure. This award recognizes the best abstract related to the field of carcinogenesis submitted by postdoctoral fellows.

The study of interest wasn’t linked. I found it here,, and they want $36 before I can read this study that our tax dollars paid for in the first place. Oh well. You can read the abstract there. It basically says they’ve finally proven out a mathematical model of how it works in rats. They note it is different in baby rats versus adult rats and monkeys. The abstract seems to admit there are still some assumptions being made. Hopefully they are remembering not to fool themselves.

FDA site on BPA here:

In closing, the fact is that after we get clean enough, safe enough, and low enough concentration, there is more harm done making it more so than just resting in the accomplishment of having done enough. Most of the time, good enough really is as good as it can get.

Eliminate the EPA and replace it with a restricted and targeted agency. Place strict guidelines and limits, and even limit funding.

Regulations are killing our country. I thank Senator Inhofe for stemming the tide of global warming alarmism, but the President and the EPA are determined to inflict the pain on us regardless. We must eliminate the EPA. Repeal the clean air act and replace it with updated and more sensible legislation. Legislation that has specific targets. It must not allow for “as low as reasonably achievable” standards. Our air and water have gotten better every year since enactment. Regulations are so bad that agricultural dust is a violation.

Carbon dioxide is an essential ingredient to life. It is not a pollutant. The other two essential ingredients to life as we know it are oxygen and water and are both far more dangerous than carbon dioxide. Oxidation in all its forms account for the majority of the damage in our world. Fire and corrosion are inexorable destroyers, always have been, always will be. Too much oxygen is even more dangerous than too much carbon dioxide. Likewise with too much water. Read the rest of this entry »

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